Physiological stress induces the metastasis marker AGR2 in breast cancer cells

被引：63

作者：

Zweitzig, Daniel R.

Smirnov, Denis A.

Connelly, Mark C.

Terstappen, Leon W. M. M.

O'Hara, S. Mark

Moran, Elizabeth ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Fels Inst Canc Res, Philadelphia, PA 19140 USA

[2] Immunicon Corp, Huntingdon, PA 19006 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2007年 / 306卷 / 1-2期

关键词：

AGR2; hAG2; ESR1; osteopontin; TFF3; circulating tumor cells; breast cancer; stress;

D O I：

10.1007/s11010-007-9562-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As an approach to understanding the factors that activate expression of tumor progression genes, the role of physiological stress in the activation of a panel of tumor cell markers was investigated. These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood. The present results identify novel physiological parameters likely to contribute to AGR2 induction in situ.

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收藏

页码：255 / 260

页数：6

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