Intracellular bacterial pathogens have evolved highly specialized mechanisms to enter and survive within their eukaryotic hosts. In order to do this, bacterial pathogens need to avoid host cell degradation and obtain nutrients and biosynthetic precursors, as well as evade detection by the host immune system. To create an intracellular niche that is favorable for replication, some intracellular pathogens inhibit the maturation of the phagosome or exit the endocytic pathway by modifying the identity of their phagosome through the exploitation of host cell trafficking pathways. In eukaryotic cells, organelle identity is determined, in part, by the composition of active Rab GTPases on the membranes of each organelle. This review describes our current understanding of how selected bacterial pathogens regulate host trafficking pathways by the selective inclusion or retention of Rab GTPases on membranes of the vacuoles that they occupy in host cells during infection.
机构:
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
Alvarez-Dominguez, C
;
Stahl, PD
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
机构:Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
Babst, M
;
Wendland, B
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
Wendland, B
;
Estepa, EJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
Estepa, EJ
;
Emr, SD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USAUniv Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
机构:
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
Alvarez-Dominguez, C
;
Stahl, PD
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
机构:Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
Babst, M
;
Wendland, B
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
Wendland, B
;
Estepa, EJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA
Estepa, EJ
;
Emr, SD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USAUniv Calif San Diego, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA