Manipulation of Rab GTPase function by intracellular bacterial pathogens

被引:163
作者
Brurnell, John H. [2 ,3 ]
Scidmore, Marci A. [1 ]
机构
[1] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
[2] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1X8, Canada
[3] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada
基金
英国惠康基金;
关键词
D O I
10.1128/MMBR.00023-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Intracellular bacterial pathogens have evolved highly specialized mechanisms to enter and survive within their eukaryotic hosts. In order to do this, bacterial pathogens need to avoid host cell degradation and obtain nutrients and biosynthetic precursors, as well as evade detection by the host immune system. To create an intracellular niche that is favorable for replication, some intracellular pathogens inhibit the maturation of the phagosome or exit the endocytic pathway by modifying the identity of their phagosome through the exploitation of host cell trafficking pathways. In eukaryotic cells, organelle identity is determined, in part, by the composition of active Rab GTPases on the membranes of each organelle. This review describes our current understanding of how selected bacterial pathogens regulate host trafficking pathways by the selective inclusion or retention of Rab GTPases on membranes of the vacuoles that they occupy in host cells during infection.
引用
收藏
页码:636 / +
页数:19
相关论文
共 212 条
[1]   LYSOSOMAL RESPONSE OF A MURINE MACROPHAGE-LIKE CELL-LINE PERSISTENTLY INFECTED WITH COXIELLA-BURNETII [J].
AKPORIAYE, ET ;
ROWATT, JD ;
ARAGON, AA ;
BACA, OG .
INFECTION AND IMMUNITY, 1983, 40 (03) :1155-1162
[2]   Legionella pneumophila -: a human pathogen that co-evolved with fresh water protozoa [J].
Albert-Weissenberger, C. ;
Cazalet, C. ;
Buchrieser, C. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (04) :432-448
[3]   Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion [J].
Allan, BB ;
Moyer, BD ;
Balch, WE .
SCIENCE, 2000, 289 (5478) :444-448
[4]   Increased expression of Rab5a correlates directly with accelerated maturation of Listeria monocytogenes phagosomes [J].
Alvarez-Dominguez, C ;
Stahl, PD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) :11459-11462
[5]   Phagocytosed live Listeria monocytogenes influences rab5-regulated in vitro phagosome-endosome fusion [J].
AlvarezDominguez, C ;
Barbieri, AM ;
Beron, W ;
WandingerNess, A ;
Stahl, PD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) :13834-13843
[6]   Autophagy is an immediate macrophage response to Legionella pneumophila [J].
Amer, AO ;
Swanson, MS .
CELLULAR MICROBIOLOGY, 2005, 7 (06) :765-778
[7]   SEQUENTIAL COUPLING BETWEEN COPII AND COPI VESICLE COATS IN ENDOPLASMIC-RETICULUM TO GOLGI TRANSPORT [J].
ARIDOR, M ;
BANNYKH, SI ;
ROWE, T ;
BALCH, WE .
JOURNAL OF CELL BIOLOGY, 1995, 131 (04) :875-893
[8]   RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM-TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES [J].
ARMSTRONG, JA ;
HART, PD .
JOURNAL OF EXPERIMENTAL MEDICINE, 1971, 134 (03) :713-+
[9]  
ATHERTON JC, 2001, HELICOBACTER PYLORI, P97
[10]   The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function [J].
Babst, M ;
Wendland, B ;
Estepa, EJ ;
Emr, SD .
EMBO JOURNAL, 1998, 17 (11) :2982-2993