DNA-end-joining: from yeast to man

被引：477

作者：

Critchlow, SE

Jackson, SP

机构：

[1] Wellcome CRC Inst, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(98)01284-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA non-homologous end-joining (NHEJ) is a crucial process that has been conserved highly throughout eukaryotic evolution. At its heart is a multiprotein complex containing the KU70-KU80 heterodimer. Recent work has identified additional proteins involved in this pathway, providing insights into the mechanism of NHEJ and revealing exciting links with the control of transcription, telomere length and chromatin structure.

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页码：394 / 398

页数：5

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