Circadian regulation of hippocampal long-term potentiation

被引:175
作者
Chaudhury, D [1 ]
Wang, LM [1 ]
Colwell, CS [1 ]
机构
[1] Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA
关键词
circadian rhythm; hippocampus; long-term potentiation; melatonin; synaptic plasticity; mice;
D O I
10.1177/0748730405276352
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The goal of this study is to investigate the possible circadian regulation of hippocampal excitability and long-term potentiation (LTP) measured by stimulating the Schaffer collaterals (SC) and recording the field excitatory postsynaptic potential (fEPSP) from the CA1 dendritic layer or the population spike (PS) from the soma in brain slices of C3H and C57 mice. These 2 strains of mice were of interest because the C3H mice secrete melatonin rhythmically while the C57 mice do not. The authors found that the magnitude of the enhancement of the PS was significantly greater in UP recorded from night slices compared to day slices of both C3H and C57 mice. They also found significant diurnal variation in the decay of UP measured with fEPSPs, with the decay slower during the night in both strains of mice. There was evidence for a diurnal rhythm in the input/output function of pyramidal neurons measured at the soma in C57 but not C3H mice. Furthermore, UP in the PS, measured in slices prepared during the day but recorded during the night, had a profile remarkably similar to the night group. Finally, PS recordings were carried out in slices from C3H mice maintained in constant darkness prior to experimentation. Again, the authors found that the magnitude of the enhancement of the PS was significantly greater in LTP recorded from subjective night slices compared to subjective day slices. These results provide the 1st evidence that an endogenous circadian oscillator modulates synaptic plasticity in the hippocampus.
引用
收藏
页码:225 / 236
页数:12
相关论文
共 60 条
[1]   Electrophysiological characterisation of the dentate gyrus in five inbred strains of mouse [J].
Bampton, ETW ;
Gray, RA ;
Large, CH .
BRAIN RESEARCH, 1999, 841 (1-2) :123-134
[2]   CIRCADIAN-RHYTHM OF SYNAPTIC EXCITABILITY IN RAT AND MONKEY CENTRAL NERVOUS-SYSTEM [J].
BARNES, CA ;
MCNAUGHTON, BL ;
GODDARD, GV ;
DOUGLAS, RM ;
ADAMEC, R .
SCIENCE, 1977, 197 (4298) :91-93
[3]   THE EFFECT OF CONSTANT LIGHT AND PHASE-SHIFTS ON A LEARNED TIME PLACE ASSOCIATION IN GARDEN WARBLERS (SYLVIA-BORIN) - HOURGLASS OR CIRCADIAN CLOCK [J].
BIEBACH, H ;
FALK, H ;
KREBS, JR .
JOURNAL OF BIOLOGICAL RHYTHMS, 1991, 6 (04) :353-365
[4]   The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system [J].
Buijs, RM ;
van Eden, CG ;
Goncharuk, VD ;
Kalsbeek, A .
JOURNAL OF ENDOCRINOLOGY, 2003, 177 (01) :17-26
[5]   Sleep deprivation impairs long-term potentiation in rat hippocampal slices [J].
Campbell, IG ;
Guinan, MJ ;
Horowitz, JM .
JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (02) :1073-1076
[6]   Rats use an ordinal timer in a daily time-place learning task [J].
Carr, JAR ;
Wilkie, DM .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES, 1997, 23 (02) :232-247
[7]   CIRCADIAN-RHYTHMS IN HIPPOCAMPAL RESPONSIVENESS TO PERFORANT PATH STIMULATION AND THEIR RELATION TO BEHAVIORAL STATE [J].
CAULLER, LJ ;
BOULOS, Z ;
GODDARD, GV .
BRAIN RESEARCH, 1985, 329 (1-2) :117-130
[8]   Circadian modulation of learning and memory in fear-conditioned mice [J].
Chaudhury, D ;
Colwell, CS .
BEHAVIOURAL BRAIN RESEARCH, 2002, 133 (01) :95-108
[9]   Melatonin blocks the induction of long-term potentiation in an N-methyl-D-aspartate independent manner [J].
Collins, DR ;
Davies, SN .
BRAIN RESEARCH, 1997, 767 (01) :162-165
[10]   Learning and circadian behavior [J].
Daan, S .
JOURNAL OF BIOLOGICAL RHYTHMS, 2000, 15 (04) :296-299