Therapeutic cloning in individual parkinsonian mice

被引：73

作者：

Tabar, Viviane ^{[1
,2
]}

Tomishima, Mark ^{[3
]}

Panagiotakos, Georgia ^{[1
]}

Wakayama, Sayaka ^{[4
]}

Menon, Jayanthi ^{[1
]}

Chan, Bill ^{[1
]}

Mizutani, Eiji ^{[4
]}

Al-Shamy, George ^{[1
]}

Ohta, Hiroshi ^{[4
]}

Wakayama, Teruhiko ^{[4
]}

Studer, Lorenz ^{[1
,3
]}

机构：

[1] Sloan Kettering Inst, Dept Neurosurg, New York, NY 10065 USA

[2] Cornell Univ, Weil Med Coll, Dept Neurosurg, New York, NY 10065 USA

[3] Sloan Kettering Inst, Dev Biol Program, New York, NY 10065 USA

[4] RIKEN, Ctr Dev Biol, Kobe, Hyogo 6500047, Japan

来源：

NATURE MEDICINE | 2008年 / 14卷 / 04期

关键词：

D O I：

10.1038/nm1732

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt) ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.

引用

页码：379 / 381

页数：3

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