mtDNA mutations and common neurodegenerative disorders

被引：58

作者：

Howell, N

Elson, JL

Chinnery, PF

Turnbull, DM ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Sch Neurol Neurobiol & Psychiat, Mitochondrial Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Migenix Corp, San Diego, CA 92130 USA

[3] Univ Texas, Med Branch, Dept Radiat Oncol, Galveston, TX 77550 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tig.2005.08.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The incidence and prevalence of Alzheimer's disease (AD) and Parkinson's disease (PD) are increasing as the population ages. Both disorders have been associated with oxidative stress and mitochondrial dysfunction, and it has been proposed that mutations in the mitochondrial genome have a key role in neurodegeneration in AD and PD patients. Two recent publications propose that heteroplasmic mtDNA mutations are involved in AD and PD. However, when these new studies are considered in relation to the sum of previous evidence, the role of mtDNA mutations in the development of either AD or PD still remains to be established.

引用

页码：583 / 586

页数：4

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