Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents

被引：68

作者：

Fadeyi, Olugbeminiyi O. ^{[1
]}

Adamson, Saudat T. ^{[2
]}

Myles, E. Lewis ^{[2
]}

Okoro, Cosmas O. ^{[1
]}

机构：

[1] Tennessee State Univ, Dept Chem, Nashville, TN 37209 USA

[2] Tennessee State Univ, Dept Biol Sci, Nashville, TN 37209 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期

关键词：

acridone; DNA; acridine; anticancer; fluorinated; tricyclic;

D O I：

10.1016/j.bmcl.2008.05.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI(50) that ranged in values from 0.13 to 26 mu M, covering a wide range of cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4172 / 4176

页数：5

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