Genetic network during neural crest induction: From cell specification to cell survival

被引：114

作者：

Steventon, B

Carmona-Fontaine, C

Mayor, R

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

[2] Univ Chile, Millennium Nucleus Dev Biol, Santiago, Chile

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 06期

基金：

英国医学研究理事会;

关键词：

neural crest; genetic cascade; cell survival; Wnt; FGF; BMP; retinoic acid;

D O I：

10.1016/j.semcdb.2005.06.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naive ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：647 / 654

页数：8

共 123 条

[1] Sox10 regulates the development of neural crest-derived melanocytes in Xenopus [J].