Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing

被引：117

作者：

Schiesser, Stefan ^{[1
]}

Hackner, Benjamin ^{[1
]}

Pfaffeneder, Toni ^{[1
]}

Mueller, Markus ^{[1
]}

Hagemeier, Christian ^{[2
]}

Truss, Matthias ^{[2
]}

Carell, Thomas ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, Ctr Integrated Prot Sci, D-81377 Munich, Germany

[2] Charite Univ Klin, Otto Heubner Ctr Kinder & Jugendmed, Klin Allgemeine Padiatrie, Lab Padiatr Mol Biol, D-10098 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 26期

关键词：

5-carboxycytosine; decarboxylation; epigenetics; isotopic labeling; stem cells; DNA METHYLATION; 5-HYDROXYMETHYLCYTOSINE; EXCISION; URACIL; 5-FORMYLCYTOSINE; 5-METHYLCYTOSINE; DEMETHYLATION; GLYCOSYLASE; CONVERSION; REPAIR;

D O I：

10.1002/anie.201202583

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eraserhead: Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5-carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5-C6 double bond. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6516 / 6520

页数：5

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