Novel expression of the goosecoid transcription factor in the embryonic mouse heart

被引：4

作者：

Conway, SJ ^{[1
]}

机构：

[1] Med Coll Georgia, Dept Cell Biol & Anat, Inst Mol Med & Genet, Augusta, GA 30912 USA

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 81卷 / 1-2期

关键词：

goosecoid; heart; outflow tract; neural crest; mouse;

D O I：

10.1016/S0925-4773(98)00235-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Goosecoid (gsc)is expressed in the organizer region of vertebrate embryos undergoing the movements of gastrulation. Likewise, the early heart tube (8.5-9.5 dpc) undergoes a similar process of Looping to bring the atrial region cranial and dorsal to the ventricular region, eventually giving rise to the four chambered heart. In order to determine whether gsc is similarly involved in heart morphogenesis, in situ hybridization and RT-PCR were used to detect gsc expression in the embryonic mouse heart. We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：187 / 191

页数：5

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