The polarization of immune cells in the tumour environment by TGFβ

被引：729

作者：

Flavell, Richard A. ^{[1
]}

Sanjabi, Shomyseh ^{[1
]}

Wrzesinski, Stephen H. ^{[1
]}

Licona-Limon, Paula ^{[1
]}

机构：

[1] Yale Univ, Sch Med, New Haven, CT 06520 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 08期

关键词：

GROWTH-FACTOR-BETA; REGULATORY T-CELLS; LARGE ESTABLISHED MELANOMA; MEMBRANE-BOUND TGF-BETA-1; MYELOID DENDRITIC CELLS; I KINASE INHIBITOR; FACTOR-KAPPA-B; ANTITUMOR IMMUNITY; NK CELLS; SUPPRESSOR-CELLS;

D O I：

10.1038/nri2808

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transforming growth factor-beta (TGF beta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the immune system. This Review covers the effects of TGF beta on natural killer (NK) cells, dendritic cells, macrophages, neutrophils, CD8(+) and CD4(+) effector and regulatory T cells, and NKT cells in animal tumour models and in patients with cancer. Collectively, many recent studies favour the hypothesis that blocking TGF beta-induced signalling in the tumour microenvironment enhances antitumour immunity and may be beneficial for cancer therapy. An overview of the current drugs and reagents available for inhibiting TGF beta-induced signalling and their phase in clinical development is also provided.

引用

页码：554 / 567

页数：14

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