Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma

被引:94
作者
Nativ, O
Sabo, E
Reiss, A
Wald, M
Madjar, S
Moskovitz, B
机构
[1] Bnai Z Med Ctr, Dept Urol, IL-31048 Haifa, Israel
[2] Bnai Z Med Ctr, Dept Pathol, IL-31048 Haifa, Israel
关键词
D O I
10.1016/S0090-4295(98)00019-3
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives. To determine the relationship between angiogenesis and various histopathologic features as well as clinical outcome in patients with localized renal cell carcinoma (RCC). Methods, Microvessel density was quantified by using immunocytochemical staining of endothelial cells for factor VIII-related antigen of 36 specimens taken from patients with pathologic Stage pT1 or pT2 RCC. All patients underwent radical nephrectomy and were followed for a mean time of 97.3 months. Results. No association was noted between microvessel count (MVC) and either cell type, architecture, or tumor size. Inverse correlation was noted between MVC and nuclear area (P = 0.006), nuclear elipticity (P = 0.016), nuclear roughness (P = 0.039), and histologic grade (P = 0.047). Patients having tumors with low MVC had significantly better survival rate compared with those with high MVC neoplasms (P = 0.0014, by Cox proportional hazards method). Conclusions, Despite lack of correlation with known predictors of survival, MVC provides independent prognostic information for patients with localized RCC. (C) 1998, Elsevier Science Inc. All rights reserved.
引用
收藏
页码:693 / 696
页数:4
相关论文
共 28 条
  • [1] BEAHRS OH, 1992, AM JOINT COMMITTEE C, P201
  • [2] RENAL-CELL CARCINOMA .2. HISTOLOGICAL INDICATORS OF PROGNOSIS
    DELAHUNT, B
    NACEY, JN
    [J]. PATHOLOGY, 1987, 19 (03) : 258 - 263
  • [3] FOLKMAN J, 1992, J BIOL CHEM, V267, P10931
  • [4] Folkman J, 1992, Semin Cancer Biol, V3, P65
  • [5] Seminars in medicine of the Beth Israel Hospital, Boston - Clinical applications of research on angiogenesis
    Folkman, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (26) : 1757 - 1763
  • [6] PROGNOSTIC-SIGNIFICANCE OF MORPHOLOGIC PARAMETERS IN RENAL-CELL CARCINOMA
    FUHRMAN, SA
    LASKY, LC
    LIMAS, C
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1982, 6 (07) : 655 - 663
  • [7] ANGIOGENIC FACTOR
    FURUKAWA, T
    YOSHIMURA, A
    SUMIZAWA, T
    HARAGUCHI, M
    AKIYAMA, S
    FUKUI, K
    ISHIZAWA, M
    YAMADA, Y
    [J]. NATURE, 1992, 356 (6371) : 668 - 668
  • [8] RENAL-CELL CARCINOMA - SURVIVAL AND PROGNOSTIC FACTORS
    GOLIMBU, M
    JOSHI, P
    SPERBER, A
    TESSLER, A
    ALASKARI, S
    MORALES, P
    [J]. UROLOGY, 1986, 27 (04) : 291 - 301
  • [9] TUMOR ANGIOGENESIS CORRELATES WITH LYMPH-NODE METASTASES IN INVASIVE BLADDER-CANCER
    JAEGER, TM
    WEIDNER, N
    CHEW, K
    MOORE, DH
    KERSCHMANN, RL
    WALDMAN, FM
    CARROLL, PR
    [J]. JOURNAL OF UROLOGY, 1995, 154 (01) : 69 - 71
  • [10] KLOPPEL G, 1986, EUR UROL, V12, P426