The 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis Phase 2 Methodological Report

被引：231

作者：

Neogi, Tuhina ^{[2
]}

Aletaha, Daniel ^{[3
]}

Silman, Alan J. ^{[4
]}

Naden, Raymond L. ^{[5
]}

Felson, David T. ^{[2
]}

Aggarwal, Rohit ^{[6
]}

Bingham, Clifton O., III ^{[7
]}

Birnbaum, Neal S. ^{[8
,9
]}

Burmester, Gerd R. ^{[10
]}

Bykerk, Vivian P. ^{[11
,44
]}

Cohen, Marc D. ^{[12
]}

Combe, Bernard ^{[13
,14
]}

Costenbader, Karen H. ^{[15
,16
]}

Dougados, Maxime ^{[17
,18
]}

Emery, Paul ^{[19
,20
]}

Ferraccioli, Gianfranco ^{[21
]}

Hazes, Johanna M. W. ^{[22
,23
]}

Hobbs, Kathryn ^{[24
]}

Huizinga, Tom W. J. ^{[25
]}

Kavanaugh, Arthur ^{[26
]}

Kay, Jonathan ^{[27
,28
]}

Khanna, Dinesh ^{[29
]}

Kvien, Tore K. ^{[30
]}

Laing, Timothy ^{[31
]}

Liao, Katherine ^{[15
,16
]}

Mease, Philip ^{[32
,33
]}

Menard, Henri A. ^{[34
]}

Moreland, Larry W. ^{[6
]}

Nair, Raj ^{[35
]}

Pincus, Theodore ^{[36
]}

Ringold, Sarah ^{[37
]}

Smolen, Josef S. ^{[3
]}

Stanislawska-Biernat, Ewa ^{[38
]}

Symmons, Deborah ^{[39
]}

Tak, Paul P. ^{[40
]}

Upchurch, Katherine S. ^{[27
,28
]}

Vencovsky, Jiri ^{[41
]}

Wolfe, Frederick ^{[42
,43
]}

Hawker, Gillian ^{[1
,44
]}

机构：

[1] Womens Coll Hosp, Dept Med, Toronto, ON M5S 1B2, Canada

[2] Boston Univ, Sch Med, Boston, MA 02118 USA

[3] Med Univ Vienna, Vienna, Austria

[4] Arthrit Res UK, Chesterfield, England

[5] Minist Hlth, Auckland, New Zealand

[6] Univ Pittsburgh, Pittsburgh, PA USA

[7] Johns Hopkins Univ, Baltimore, MD USA

[8] Calif Pacific Med Ctr, San Francisco, CA USA

[9] Univ Calif San Francisco, San Francisco, CA 94143 USA

[10] Free Univ Berlin, Charite Hospital Univ Med Berlin, D-1000 Berlin, Germany

[11] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[12] Natl Jewish Med & Res Ctr, Denver, CO USA

[13] Lapeyronie Hosp, Montpellier, France

[14] Univ Montpellier I, Montpellier, France

[15] Brigham & Womens Hosp, Boston, MA 02115 USA

[16] Harvard Univ, Boston, MA 02115 USA

[17] Hop Cochin, AP HP, F-75674 Paris, France

[18] Paris Descartes Univ, Paris, France

[19] Univ Leeds, Leeds, W Yorkshire, England

[20] NIHR Leeds Biomed Res Unit, Leeds, W Yorkshire, England

[21] Univ Cattolica Sacro Cuore, Sch Med, I-00168 Rome, Italy

[22] Erasmus MC, Rotterdam, Netherlands

[23] Univ Rotterdam, Rotterdam, Netherlands

[24] Univ Colorado, Sch Med, Denver, CO USA

[25] Leiden Univ, Med Ctr, Leiden, Netherlands

[26] Univ Calif San Diego, San Diego, CA 92103 USA

[27] UMassMem Med Ctr, Worcester, MA USA

[28] Univ Massachusetts, Sch Med, Worcester, MA USA

[29] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[30] Diakonhjemmet Hosp, Oslo, Norway

[31] Univ Michigan, Ann Arbor, MI 48109 USA

[32] Univ Washington, Seattle, WA 98195 USA

[33] Swedish Med Ctr, Seattle, WA USA

[34] McGill Univ, Ctr Hlth, Montreal, PQ, Canada

[35] Univ N Carolina, Chapel Hill, NC USA

[36] New York Univ Hosp Joint Dis, New York, NY USA

[37] Seattle Childrens Hosp, Seattle, WA USA

[38] Inst Rheumatol, Warsaw, Poland

[39] Univ Manchester, Manchester, Lancs, England

[40] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[41] Inst Rheumatol, Prague, Czech Republic

[42] Natl Data Bank Rheumat Dis, Wichita, KS USA

[43] Univ Kansas, Wichita, KS USA

[44] Univ Toronto, Toronto, ON, Canada

来源：

ARTHRITIS AND RHEUMATISM | 2010年 / 62卷 / 09期

关键词：

CITRULLINATED PEPTIDE;

D O I：

10.1002/art.27580

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. The American College of Rheumatology and the European League Against Rheumatism have developed new classification criteria for rheumatoid arthritis (RA). The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set. Methods. Twenty-four expert RA clinicians (12 from Europe and 12 from North America) participated in Phase 2. A consensus-based decision analysis approach was used to identify factors (and their relative weights) that influence the probability of "developing RA," complemented by data from the Phase 1 study. Patient case scenarios were used to identify and reach consensus on factors important in determining the probability of RA development. Decision analytic software was used to derive the relative weights for each of the factors and their categories, using choice-based conjoint analysis. Results. The expert panel agreed that the new classification criteria should be applied to individuals with undifferentiated inflammatory arthritis in whom at least 1 joint is deemed by an expert assessor to be swollen, indicating definite synovitis. In this clinical setting, they identified 4 additional criteria as being important: number of joints involved and site of involvement, serologic abnormality, acute-phase response, and duration of symptoms in the involved joints. These criteria were consistent with those identified in the Phase 1 data-driven approach. Conclusion. The consensus-based, decision analysis approach used in Phase 2 complemented the Phase 1 efforts. The 4 criteria and their relative weights form the basis of the final criteria set.

引用

页码：2582 / 2591

页数：10

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