Gabapentin suppresses cortical spreading depression susceptibility

被引：35

作者：

Hoffmann, Ulrike ^{[1
]}

Dilekoz, Ergin ^{[1
]}

Kudo, Chiho ^{[1
]}

Ayata, Cenk ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Neurovasc Res Lab, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Stroke Serv & Neurosci Intens Care Unit,Dept Neur, Charlestown, MA 02129 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 09期

关键词：

cortex; electrophysiology; gabapentin; rat; spreading depression; CALCIUM-CHANNEL; BRAIN-INJURY; DEPOLARIZATIONS; DRUG; RATS; NEURONTIN; BLOCKADE; PLASMA;

D O I：

10.1038/jcbfm.2010.92

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its alpha(2)delta subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1588-1592; doi:10.1038/jcbfm.2010.92; published online 30 June 2010

引用

页码：1588 / 1592

页数：5

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