Early Short-Term Vagal Nerve Stimulation Attenuates Cardiac Remodeling After Reperfused Myocardial Infarction

被引：48

作者：

Uemura, Kazunori ^{[1
]}

Zheng, Can ^{[2
]}

Li, Meihua ^{[1
]}

Kawada, Toru ^{[1
]}

Sugimachi, Masaru ^{[1
]}

机构：

[1] Natl Cardiovasc Ctr, Res Inst, Dept Cardiovasc Dynam, Adv Med Engn Ctr, Suita, Osaka 5658565, Japan

[2] Kochi Med Sch, Dept Cardiovasc Control, Nankoku, Kochi, Japan

来源：

JOURNAL OF CARDIAC FAILURE | 2010年 / 16卷 / 08期

关键词：

Hypertrophy; cardiac function; acute inflammatory response; matrix metalloproteinase; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; HEART-FAILURE; INFLAMMATORY RESPONSE; ISCHEMIA-REPERFUSION; MAST-CELLS; SURVIVAL; INJURY; ACETYLCHOLINE; INHIBITION;

D O I：

10.1016/j.cardfail.2010.03.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Vagal nerve stimulation (VS) has been suggested to be an effective adjunct to reperfusion therapy in myocardial infarction (MI) However. the effect of VS on left ventricular (LV) remodeling after reperfused MI has not been examined Methods and Results: We investigated the effects of early. brief VS on acute inflammatory reactions (study I) and chronic LV remodeling (study 2) in a rabbit model of reperfused MI In study I. rabbits were subjected to 60-minute coronary artery occlusion followed by reperfusion alone (MI. n = 8) or treated with 24-hour VS (MI-VS. n = 8) At 24 hours after ischemia-reperfusion. MI-VS rabbits showed significantly decreased myocardial infiltration of neutrophils and reduced myocardial expressions of tumor necrosis factor-a and matrix metalloproteinase-8 and -9, compared with MI rabbits Myocardial expression of interleukin-6 was not affected by VS In study 2. rabbits were subjected to coronary occlusion and reperfusion alone (n = 16) or treated with VS for 3 clays (n = 14) At 8 weeks after ischemia-reperfusion. MI-VS rabbits showed significantly improved LV dysfunction and dilatation, and significantly reduced infarct size, infarct wall thinning, and LV weight compared with MI rabbits Conclusion: Early. short-term VS attenuates LV remodeling after reperfused MI, which may be associated with suppression of acute inflammatory reactions (J Cardiac Fail 2010.16 689-699)

引用

页码：689 / 699

页数：11

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