DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

被引：372

作者：

Fienberg, AA

Hiroi, N

Mermelstein, PG

Song, WJ

Snyder, GL

Nishi, A

Cheramy, A

O'Callaghan, JP

Miller, DB

Cole, DG

Corbett, R

Haile, CN

Cooper, DC

Onn, SP

Grace, AA

Ouimet, CC

White, FJ

Hyman, SE

Surmeier, DJ

Girault, JA

Nestler, EJ

Greengard, P

机构：

[1] Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA

[2] Yale Univ, Sch Med, Lab Mol Psychiat, New Haven, CT 06519 USA

[3] Connecticut Mental Hlth Ctr, New Haven, CT 06508 USA

[4] Univ Tennessee, Dept Anat & Neurobiol, Coll Med, Memphis, TN 38163 USA

[5] Coll France, INSERM, U114, F-75005 Paris, France

[6] Ctr Dis Control & Prevent, NIOSH, Morgantown, WV 26505 USA

[7] Harvard Univ, Sch Med, Boston, MA 02114 USA

[8] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[9] Hoechst Marion Roussel Inc, Somerville, NJ 08807 USA

[10] Finch Univ Hlth Sci Chicago Med Sch, Dept Neurosci, N Chicago, IL 60064 USA

[11] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA

[12] Florida State Univ, Program Neurosci, Tallahassee, FL 32306 USA

来源：

SCIENCE | 1998年 / 281卷 / 5378期

关键词：

D O I：

10.1126/science.281.5378.838

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

引用

页码：838 / +

页数：5

共 47 条

[1] EXCITATORY AND INHIBITORY EFFECTS OF DOPAMINE ON NEURONAL-ACTIVITY OF THE CAUDATE-NUCLEUS NEURONS INVITRO [J].