Co-dependence of bone and energy metabolisms

被引：20

作者：

Wei, Jianwen ^{[1
]}

Ducy, Patricia ^{[2
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, Coll Phys & Surg, New York, NY 10032 USA

[2] Columbia Univ, Dept Pathol, Coll Phys & Surg, New York, NY 10032 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 503卷 / 01期

关键词：

Bone formation; Bone resorption; Leptin; Serotonin; Osteocalcin; Sympathetic nervous system; AMPHETAMINE-REGULATED TRANSCRIPT; SYMPATHETIC-NERVOUS-SYSTEM; LEPTIN RECEPTOR; TYROSINE-PHOSPHATASE; WEIGHT HOMEOSTASIS; NEUROMEDIN-U; MASS; OSTEOCALCIN; MICE; EXPRESSION;

D O I：

10.1016/j.abb.2010.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growing number of genetically modified mouse models available but also of the possibility to delete one or several genes at will in a defined time frame or in a specific cell type or tissue(s) has open new possibilities for the study of whole animal physiology. This in vivo approach has been especially successful in uncovering a regulatory loop linking the control of energy metabolism and the regulation of bone remodeling. This review is intended to summarize the key events that led to the identification and the characterization of the different steps and molecules constituting this regulatory network. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：35 / 40

页数：6

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