Serum amyloid P component binding to Shiga toxin 2 requires both A subunit and B pentamer

被引：22

作者：

Marcato, P ^{[1
]}

Vander Helm, K ^{[1
]}

Mulvey, GL ^{[1
]}

Armstrong, GD ^{[1
]}

机构：

[1] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 10期

关键词：

D O I：

10.1128/IAI.71.10.6075-6078.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains.

引用

页码：6075 / 6078

页数：4

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