Combination therapy for early Alzheimer's disease: What are we waiting for?

被引：20

作者：

Doraiswamy, PM

Steffens, DC

机构：

[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27710 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 1998年 / 46卷 / 10期

关键词：

D O I：

10.1111/j.1532-5415.1998.tb04556.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The practical pharmacological approaches currently available to palliate the cognitive and functional losses in early Alzheimer's disease (AD) include cholinesterase inhibitors (ChEI), antioxidants (e.g., vitamin E), anti-inflammatory agents, estrogen, seligiline, vasoactive agents, and ginkgo biloba. Reviewing available data on these therapies and using models from medical illnesses such as cancer and hypertension, we highlight the urgent need for evaluating combination therapies in early AD.

引用

页码：1322 / 1324

页数：3

共 24 条

[1] COREYBLOOM AR, 1998, INT J GERIATR PSYCHO, P55
[2] Doraiswamy PM, 1998, J CLIN PSYCHIAT, V59, P6
[3] DORAISWAMY PM, 1991, BAILLIERES INT CLIN, V5, P159
[4] DORAISWAMY PM, 1996, PRIMARY PSYCHIAT NOV, P56
[5] From molecular structure to Alzheimer therapy
Giacobini, E
[J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1997, 74 (03) : 225 - 241
[6] Metrifonate for Alzheimer's disease - Is the next cholinesterase inhibitor better?
Knopman, DS
[J]. NEUROLOGY, 1998, 50 (05) : 1203 - 1205
[7] An update on primary drug therapies for Alzheimer disease
Knopman, DS
Morris, JC
[J]. ARCHIVES OF NEUROLOGY, 1997, 54 (11) : 1406 - 1409
[8] A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia
LeBars, PL
Katz, MM
Berman, N
Itil, TM
Freedman, AM
Schatzberg, AF
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16): : 1327 - 1332
[9] Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
McGeer, PL
Schulzer, M
McGeer, EG
[J]. NEUROLOGY, 1996, 47 (02) : 425 - 432
[10] Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease
Morris, JC
Cyrus, PA
Orazem, J
Mas, J
Bieber, F
Ruzicka, BB
Gulanski, B
[J]. NEUROLOGY, 1998, 50 (05) : 1222 - 1230

← 1 2 3 →