The complement system and adaptive immunity

被引：93

作者：

Fearon, DT ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Wellcome Trust Immunol Unit, Cambridge CB2 2SP, England

来源：

SEMINARS IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

B lymphocyte; CD19; CD21; CD22; complement;

D O I：

10.1006/smim.1998.0137

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system covalently attaches C3d to microbial antigens which binds to CR2 on B lymphocytes, leading to a markedly enhanced adaptive immune response to that antigen. The enhancement is mediated by the cross-linking of the CR2-CD19 complex to mIg which augments the activation of several intracellular signalling pathways. Two additional receptors of the B lymphocyte, Fc gamma RIIB and CD22, have opposing effects when cross-linked to mIg, the former suppressing signalling by recruiting the inositol phosphatase, SHIP, and the latter by activating the phosphotyrosine phosphatase, SHP-1. Two principles emerge from these studies: innate immunity guides the adaptive immune response, and activation of the B lymphocyte is determined by co-receptors which evaluate the biological characteristics of antigen.

引用

页码：355 / 361

页数：7

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