Small peptide nanofibers as the matrices of molecular hydrogels for mimicking enzymes and enhancing the activity of enzymes

被引:236
作者
Gao, Yuan [1 ]
Zhao, Fan [1 ]
Wang, Qigang [2 ]
Zhang, Ye [1 ]
Xu, Bing [1 ]
机构
[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA
[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
基金
美国国家科学基金会;
关键词
SUPRAMOLECULAR HYDROGELS; ENZYMATIC HYDROGELATION; IMMOBILIZED ENZYMES; ARTIFICIAL ENZYMES; ORGANIC-SOLVENTS; CATALYSIS; DESIGN; CELLS; HYDROLYSIS; STABILITY;
D O I
10.1039/b919450a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Enzymes, together with the process of self-assembly, constitute necessary components of the foundation of life on the nanometre scale. The exceedingly high efficiency and selectivity exhibited by enzymes for catalyzing biotransformations naturally lead to the exploration of enzyme mimics and the applications of enzymes in industrial biotransformations. While the mimicking of enzymes aims to preserve the essence of enzymes in a simpler system than proteins, industrial biotransformations demand high activity and stability of enzymes. Recent research suggests that small peptide-based nanofibers in the form of molecular hydrogels can provide a general platform to achieve both important goals. This tutorial review will introduce the recent progress of these research activities on small peptide-based nanomaterials for catalysis and hopes to provide a starting point for further explorations that ultimately may lead to practical applications of enzymes and enzyme mimics for addressing important societal problems in energy, environment, and health.
引用
收藏
页码:3425 / 3433
页数:9
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