A divergent approach to apoptolidin and FD-891: asymmetric preparation of a common intermediate

被引：21

作者：

Chng, SS ^{[1
]}

Xu, J ^{[1
]}

Loh, TP ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 27期

关键词：

apoptolidin; FD-891; divergent synthesis;

D O I：

10.1016/S0040-4039(03)01173-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4997 / 5000

页数：4

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