New models for cancer research: human cancer stem cell xenografts

被引：49

作者：

Baiocchi, Marta ^{[1
]}

Biffoni, Mauro ^{[1
]}

Ricci-Vitiani, Lucia ^{[1
]}

Pilozzi, Emanuela ^{[2
]}

De Maria, Ruggero ^{[1
,3
]}

机构：

[1] Ist Super Sanita, Dipartimento Ematol Oncol & Med Mol, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, St Andreas Hosp, Dept Expt Med, Rome, Italy

[3] Mediterranean Inst Oncol, Catania, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 04期

关键词：

TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; MELANOMA-CELLS; IDENTIFICATION; GLIOBLASTOMA; CARCINOMA; GROWTH;

D O I：

10.1016/j.coph.2010.05.002

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies.

引用

页码：380 / 384

页数：5

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