Four Steps to Optic Nerve Regeneration

被引：77

作者：

Moore, Darcie L. ^{[1
]}

Goldberg, Jeffrey L. ^{[2
]}

机构：

[1] ETH, Inst Cell Biol, CH-8093 Zurich, Switzerland

[2] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA

来源：

JOURNAL OF NEURO-OPHTHALMOLOGY | 2010年 / 30卷 / 04期

基金：

美国国家卫生研究院;

关键词：

RETINAL GANGLION-CELLS; CILIARY NEUROTROPHIC FACTOR; CHONDROITIN SULFATE PROTEOGLYCANS; MYELIN-ASSOCIATED GLYCOPROTEIN; PROMOTES AXONAL REGENERATION; ENHANCE NEURONAL SURVIVAL; RAT SYMPATHETIC NEURONS; NITRIC-OXIDE SYNTHASE; SPINAL-CORD-INJURY; FETAL BRAIN GRAFTS;

D O I：

10.1097/WNO.0b013e3181e755af

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The failure of the optic nerve to regenerate after injury or in neurodegenerative disease remains a major clinical and scientific problem. Retinal ganglion cell (RGC) axons course through the optic nerve and carry all the visual information to the brain, but after injury, they fail to regrow through the optic nerve and RGC cell bodies typically die, leading to permanent loss of vision. There are at least 4 hurdles to overcome in preserving RGCs and regenerating their axons: 1) increase RGC survival, 2) overcome the inhibitory environment of the optic nerve, 3) enhance RGC intrinsic axon growth potential, and 4) optimize the mapping of RGC connections back into their targets in the brain.

引用

页码：347 / 360

页数：14

共 203 条

[1]

GROWTH AND CONNECTIVITY OF AXOTOMIZED RETINAL NEURONS IN ADULT-RATS WITH OPTIC NERVES SUBSTITUTED BY PNS GRAFTS LINKING THE EYE AND THE MIDBRAIN [J].