Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma

被引：30

作者：

Kallio, JP

Hirvikoski, P

Helin, H

Kellokumpu-Lehtinen, P

Luukkaala, T

Tammela, TLJ

Martikainen, PM

机构：

[1] Tampere Univ Hosp, Dept Urol, FIN-33521 Tampere, Finland

[2] Oulu Univ Hosp, Dept Pathol, FIN-90029 Oulu, Finland

[3] Tampere Univ Hosp, Dept Pathol, FIN-33521 Tampere, Finland

[4] Tampere Univ Hosp, Dept Oncol, FIN-33521 Tampere, Finland

[5] Univ Tampere, Sch Med, FIN-33521 Tampere, Finland

[6] Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 07期

关键词：

renal cell carcinoma; epidermal growth factor receptor; prognosis;

D O I：

10.1038/sj.bjc.6601241

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidermal growth factor receptor (EGFR) is a key factor in tumorigenesis. The association between EGFR expression and prognosis in renal cell carcinoma (RCC) is not clear. In our study of 134 RCCs, the cellular location of immunostaining was evaluated and patients with EGFR-positive tumours with prominent membranous staining had a good prognosis. Their overall survival was significantly longer (P=0.004) than that of patients with either EGFR-negative tumours or with mainly cytoplasmic staining. However, further studies on the different EGFR expression patterns in RCC are needed to clarify their role in the progression of the disease.

引用

页码：1266 / 1269

页数：4

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