Gold nanoshell bioconjugates for molecular imaging in living cells

被引：266

作者：

Loo, C ^{[1
]}

Hirsch, L ^{[1
]}

Lee, MH ^{[1
]}

Chang, E ^{[1
]}

West, J ^{[1
]}

Halas, NJ ^{[1
]}

Drezek, R ^{[1
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77251 USA

来源：

OPTICS LETTERS | 2005年 / 30卷 / 09期

关键词：

D O I：

10.1364/OL.30.001012

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Advances in scattering-based optical imaging technologies offer a new approach to noninvasive point-of-care detection, diagnosis, and monitoring of cancer. Emerging photonics technologies provide a cost-effective means to image tissue in vivo with high resolution in real time. Advancing the clinical potential of these imaging strategies requires the development of optical contrast agents targeted to specific molecular signatures of disease. We describe the use of a novel class of contrast agents based on nanoshell bioconjugates for molecular imaging in living cells. Nanoshells offer significant advantages over conventional imaging probes including continuous and broad wavelength tunability, far greater scattering and absorption coefficients, increased chemical stability, and improved biocompatibility. We show that nanoshell bioconjugates can be used to effectively target and image human epidermal growth factor receptor 2 (HER2), a clinically relevant biomarker, in live human breast carcinoma cells. (c) 2005 Optical Society of America.

引用

页码：1012 / 1014

页数：3

共 16 条

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