Genetic Patterns of Correlation Among Subcortical Volumes in Humans: Results From a Magnetic Resonance Imaging Twin Study

被引：43

作者：

Eyler, Lisa T. ^{[1
,2
]}

Prom-Wormley, Elizabeth ^{[3
,4
,5
]}

Fennema-Notestine, Christine ^{[1
]}

Panizzon, Matthew S. ^{[1
]}

Neale, Michael C. ^{[3
,4
,5
]}

Jernigan, Terry L. ^{[1
,6
]}

Fischl, Bruce ^{[7
,8
]}

Franz, Carol E. ^{[1
]}

Lyons, Michael J. ^{[9
]}

Stevens, Allison ^{[7
,8
]}

Pacheco, Jennifer ^{[7
,8
]}

Perry, Michele E. ^{[1
,6
]}

Schmitt, J. Eric ^{[3
,4
,5
]}

Spitzer, Nicholas C. ^{[10
]}

Seidman, Larry J. ^{[11
]}

Thermenos, Heidi W. ^{[11
]}

Tsuang, Ming T. ^{[1
,12
,13
,16
]}

Dale, Anders M. ^{[14
,15
]}

Kremen, William S. ^{[1
,12
,16
]}

机构：

[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[2] VA San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr, San Diego, CA USA

[3] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA

[4] Virginia Commonwealth Univ, Dept Human Genet, Richmond, VA USA

[5] Virginia Commonwealth Univ, Dept Mol Genet, Richmond, VA USA

[6] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA

[7] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Boston Univ, Dept Psychol, Boston, MA 02215 USA

[10] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[11] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[12] Univ Calif San Diego, Ctr Behav Genom, La Jolla, CA 92093 USA

[13] Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA

[14] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

[15] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[16] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA

来源：

HUMAN BRAIN MAPPING | 2011年 / 32卷 / 04期

基金：

美国国家卫生研究院;

关键词：

behavioral genetics; hippocampus; amygdala; striatum; pallidum; caudate; putamen; thalamus; ventricles; FACTOR VAL66MET POLYMORPHISM; VIETNAM ERA TWIN; NEUROTROPHIC FACTOR; BRAIN STRUCTURE; HIPPOCAMPAL VOLUMES; MULTIVARIATE; MRI; SEGMENTATION; MORPHOLOGY; AMYGDALA;

D O I：

10.1002/hbm.21054

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Little is known about genetic influences on the volume of subcortical brain structures in adult humans, particularly whether there is regional specificity of genetic effects. Understanding patterns of genetic covariation among volumes of subcortical structures may provide insight into the development of individual differences that have consequences for cognitive and emotional behavior and neuropsychiatric disease liability. We measured the volume of 19 subcortical structures (including brain and ventricular regions) in 404 twins (110 monozygotic and 92 dizygotic pairs) from the Vietnam Era Twin Study of Aging and calculated the degree of genetic correlation among these volumes. We then examined the patterns of genetic correlation through hierarchical cluster analysis and by principal components analysis. We found that a model with four genetic factors best fit the data: a Basal Ganglia/Thalamus factor; a Ventricular factor; a Limbic factor; and a Nucleus Accumbens factor. Homologous regions from each hemisphere loaded on the same factors. The observed patterns of genetic correlation suggest the influence of multiple genetic influences. There is a genetic organization among structures which distinguishes between brain and cerebrospinal fluid spaces and between different subcortical regions. Further study is needed to understand this genetic patterning and whether it reflects influences on early development, functionally dependent patterns of growth or pruning, or regionally specific losses due to genes involved in aging, stress response, or disease. Hum Brain Mapp 32:641-653, 2011. (C) 2010 Wiley-Liss, Inc.

引用

页码：641 / 653

页数：13

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