Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer

被引：134

作者：

Jain, Rakesh K. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Edwin L Steele Lab Tumour Biol,Dept Radiat Oncol, Boston, MA 02114 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1038/nrc2346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The importance of multidisciplinary translational clinical trials is obvious; however, making them work is complex and challenging. Here I present an argument for designing and implementing multidisciplinary mechanistic trials and present the lessons our team at the Massachusetts General Hospital Cancer Center has learned from two such trials in cancer patients with locally advanced rectal carcinomas and recurrent glioblastomas.

引用

页码：309 / 316

页数：8

共 66 条

[1]

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[2]

BATCHELOR TT, 2008, P AM ASS CANC RES AN

[3]

Interstitial fluid pressure in intracranial tumours in patients and in rodents [J].

Boucher, Y ;

Salehi, H ;

Witwer, B ;

Harsh, GR ;

Jain, RK .

BRITISH JOURNAL OF CANCER, 1997, 75 (06) :829-836

[4]

BOUCHER Y, 1991, CANCER RES, V51, P6691

[5]

Angiogenesis in life, disease and medicine [J].

Carmeliet, P .

NATURE, 2005, 438 (7070) :932-936

[6]

Carreira CM, 2001, CANCER RES, V61, P8079

[7]

Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography:: A pilot study [J].

Chen, Wei ;

Delaloye, Sibylle ;

Silverman, Daniel H. S. ;

Geist, Cheri ;

Czernin, Johannes ;

Sayre, James ;

Satyamurthy, Nagichettiar ;

Pope, Whitney ;

Lai, Albert ;

Phelps, Michael E. ;

Cloughesy, Timothy .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (30) :4714-4721

[8]

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood [J].

Duda, Dan G. ;

Cohen, Kenneth S. ;

Scadden, David T. ;

Jain, Rakesh K. .

NATURE PROTOCOLS, 2007, 2 (04) :805-810

[9]

Discovery of vascular permeability factor (VPF) [J].

Dvorak, HF .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (05) :522-526

[10]

Ellis LM, 2006, SEMIN ONCOL, V33, pS1, DOI 10.1053/j.seminoncol.2006.08.002

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