Mature adipocytes may be a source of stem cells for tissue engineering

被引：57

作者：

Fernyhough, M. E. ^{[1
]}

Hausman, G. J. ^{[2
]}

Guan, L. L. ^{[3
]}

Okine, E. ^{[3
]}

Moore, S. S. ^{[3
]}

Dodson, M. V. ^{[1
]}

机构：

[1] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA

[2] USDA, Poultry Proc & Swine Physiol Res Unit, Agr Res Serv, Richard B Russell Agr Res Ctr, Athens, GA 30605 USA

[3] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 368卷 / 03期

关键词：

adipose tissue; stromal vascular fraction; mature adipocyte proliferation; mature adipocytes; dedifferentiation in vitro; tissue regeneration; stem cells;

D O I：

10.1016/j.bbrc.2008.01.113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Adipose tissue contains a large portion of stem cells. These cells appear morphologically like fibroblasts and are primarily derived from the stromal cell fraction. Mature (lipid-filled) adipocytes possess the ability to become proliferative cells and have been shown to produce progeny cells that possess the same morphological (fibroblast-like) appearance as the stem cells from the stromal fraction. A closer examination of mature adipocyte-derived progeny cells may prove to be an emerging area of growth/metabolic physiology that may modify present thinking about adipose tissue renewal capabilities. Knowledge of these cells may also prove beneficial in cell-based therapies for tissue repair, regeneration, or engineering. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：455 / 457

页数：3

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