To be or not to BMP

被引：21

作者：

Eng, C ^{[1
]}

机构：

[1] Ohio State Univ, Clin Canc Genet Program, Ctr Comprehens Canc, Columbus, OH 43210 USA

[2] Ohio State Univ, Human Canc Genet Program, Ctr Comprehens Canc, Columbus, OH 43210 USA

[3] Ohio State Univ, Div Human Genet, Dept Internal Med, Columbus, OH 43210 USA

[4] Univ Cambridge, CRC, Human Canc Genet Res Grp, Cambridge CB2 2QQ, England

来源：

NATURE GENETICS | 2001年 / 28卷 / 02期

关键词：

D O I：

10.1038/88802

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Three years after MADH4 (also known as SMAD4) was identified as a gene critical to juvenile polyposis, BMPR1A, encoding a receptor in the same pathway, has been identified as another susceptibility gene. The TGF beta /BMP superfamily of molecules has not only been shown to be defective in neoplasia but also in the non-cancer developmental syndromes primary pulmonary hypertension and hereditary hemorrhagic telangiectasia.

引用

页码：105 / 107

页数：3

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