Neutrophil clearance: when the party is over, clean-up begins

被引:240
作者
Bratton, Donna L. [1 ]
Henson, Peter M. [1 ]
机构
[1] Natl Jewish Hlth, Denver, CO 80206 USA
关键词
APOPTOTIC CELL CLEARANCE; PHOSPHOLIPID SCRAMBLASE-1; NADPH OXIDASE; MACROPHAGES; PHAGOCYTOSIS; RESOLUTION; RELEASE; DEATH; GAMMA; RECEPTOR;
D O I
10.1016/j.it.2011.04.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Maintenance of circulating, functional neutrophils and their robust recruitment to tissues in response to injury and/or microbial infection are crucial for host defense. Equally important, although less well understood, are the processes for removal of these short-lived cells. Here, we review recent findings of novel neutrophil characteristics that determine removal. These neutrophil-derived signals, in turn, can shape the responses of other cells and surrounding tissues and promote a return to homeostasis. If not removed, dying neutrophils disintegrate and release phlogistic cargo that can further contribute to ongoing inflammation, tissue destruction, or autoimmunity.
引用
收藏
页码:350 / 357
页数:8
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