High frequency of resistance to the drugs isoniazid and rifampicin among tuberculosis cases in the City of Cabo de Santo Agostinho, an urban area in Northeastern Brazil

被引：11

作者：

Baliza, Marcilio ^{[1
,7
]}

Bach, Artur Henrique ^{[1
]}

de Queiroz, Gabriel Lobo ^{[1
]}

Melo, Ines Cardoso ^{[2
]}

Carneiro, Maria Madileuza ^{[3
]}

Pessoa Militao de Albuquerque, Maria de Fatima ^{[1
]}

Suffys, Philip ^{[4
]}

Rodrigues, Laura ^{[5
]}

Ximenes, Ricardo ^{[6
]}

Lucena-Silva, Norma ^{[1
,8
]}

机构：

[1] Fundacao Oswaldo Cruz, Ctr Pesquisas Aggeu Magalhaes, Dept Imunol, BR-50670420 Recife, PE, Brazil

[2] Secretaria Saude do Cabo de Santo Agostinho, Posto Saude Herbert Souza, Cabo de Santo Agostinho, PE, Brazil

[3] Secretaria Saude do Estado Pernambuco, Cent Lab, Recife, PE, Brazil

[4] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Dept Micobacterioses, Rio De Janeiro, Brazil

[5] London Sch Hyg & Trop Med, Dept Epidemiol, London WC1, England

[6] Univ Fed Pernambuco, Dept Trop Med, Recife, PE, Brazil

[7] Univ Fed Reconcavo Bahia, Ctr Ciencias Saude, Santo Antonio Jesus, BA, Brazil

[8] Inst Materno Infantil Prof Fernando Figueira, Serv Oncol, Mol Biol Lab, Recife, PE, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2008年 / 41卷 / 01期

关键词：

tuberculosis; drug resistance; multidrug resistance; risk factors;

D O I：

10.1590/S0037-86822008000100003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

The objective of the present study was to investigate the frequency and risk factors for developing multidrug- resistant tuberculosis in Cabo de Santo Agostinho, PE. This was a prospective study conducted from 2000 to 2003, in which suspected cases were investigated using bacilloscopy and culturing. Out of 232 confirmed cases of tuberculosis, culturing and antibiotic susceptibility tests were performed on 174. Thirty- five of the 174 cultures showed resistance to all drugs. The frequencies of primary and acquired resistance to any drug were 14% and 50% respectively, while the frequencies of primary and acquired multidrug resistance were 8.3% and 40%. Previous tuberculosis treatment and abandonment of treatment were risk factors for drug resistance. The high levels of primary and acquired resistance to the combination of isoniazid and rifampicin contributed towards the difficulties in controlling tuberculosis transmission in the city.

引用

页码：11 / 16

页数：6

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