Inclusion of a photosensitizer in liposomes formed by DMPC/Gemini surfactant: Correlation between physicochemical and biological features of the complexes

被引：68

作者：

Bombelli, C

Caracciolo, G

Di Profio, P

Diociaiuti, M

Luciani, P

Mancini, G

Mazzuca, C

Marra, M

Molinari, A

Monti, D

Toccacieli, L

Venanzi, M

机构：

[1] CNR, Ist Metodol Chim, Sez Meccan Reaz, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[3] CEMIN, Ctr Eccellenza Mat Innovat Nanostrutt Appl Chim F, I-06123 Perugia, Italy

[4] Univ Perugia, Dipartimento Chim, I-06123 Perugia, Italy

[5] Ist Super Sanita, Dipartimento Tecnol & Salute, I-00161 Rome, Italy

[6] Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, I-00133 Rome, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 15期

关键词：

D O I：

10.1021/jm050182d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.

引用

页码：4882 / 4891

页数：10

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