Cutaneous penetration of bisphenol A in pig skin

被引:33
作者
Kaddar, Nisrin [1 ,2 ]
Harthe, Catherine [1 ,3 ]
Dechaud, Henri [1 ,2 ,3 ]
Mappus, Elizabeth [1 ]
Pugeat, Michel [1 ,4 ]
机构
[1] INSERM, U863, F-69373 Lyon 08, France
[2] Univ Lyon 1, F-69365 Lyon, France
[3] Hamilton Civils Lyon, Serv Radioanalyse, Ctr Med Nucl, Bron, France
[4] Hop Neurol & Cardiol, Fed Endocrinol, Bron, France
来源
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2008年 / 71卷 / 08期
关键词
D O I
10.1080/15287390801906824
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Bisphenol A (BPA) is an endocrine disruptor with weak estrogenic activity, used in epoxy resin and polycarbonate plastic. Human exposure may occur by contamination from food or food-contact material and by occupational scenarios. Occupational health hazards may be associated with allergic contact dermatitis (ACD) secondary to BPA exposure. Most ACD occurs in workers handling BPA products, such as plastic-product workers, and those exposed to epoxy adhesive tapes, foams, and dental products. The present study examined in vitro cutaneous penetration of BPA through pig skin, using a Franz cell. After 2, 5, and 10 h of exposure, total BPA skin content was 3, 6.9, and 11.4% of the applied dose, respectively. BPA remained essentially on the skin surface and penetration mainly accumulated in the dermis. As the pig skin model is a reliable predictor of percutaneous penetration in humans, these findings may be reassuring for workers in contact with BPA-based products.
引用
收藏
页码:471 / 473
页数:3
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