In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma

被引：91

作者：

Koo, KA

Sung, SH

Park, OH

Kim, SH

Lee, KY

Kim, YC

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

[3] Elcom Sci Co Ltd, Seoul, South Korea

[4] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

PLANTA MEDICA | 2005年 / 71卷 / 08期

关键词：

D O I：

10.1055/s-2005-871213

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'- acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 mu M.

引用

页码：778 / 780

页数：3

共 20 条

[1]

ALBERTO P, 2003, J NAT PRODUCTS, V66, P1606

[2] POLIUMOSIDE, A CAFFEIC GLYCOSIDE ESTER FROM TEUCRIUM-BELION [J].