Exposure-Specific and Age-Specific Attack Rates for Ebola Virus Disease in Ebola-Affected Households, Sierra Leone

被引：42

作者：

Bower, Hilary ^{[1
]}

Johnson, Sembia ^{[2
]}

Bangura, Mohamed S. ^{[2
]}

Kamara, Alie Joshua ^{[2
]}

Kamara, Osman ^{[2
]}

Mansaray, Saidu H. ^{[2
]}

Sesay, Daniel ^{[2
]}

Turay, Cecilia ^{[2
]}

Checchi, Francesco ^{[3
]}

Glynn, Judith R. ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, London, England

[2] Save Children, Freetown, Sierra Leone

[3] Save Children, London, England

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 08期

基金：

英国惠康基金;

关键词：

RISK-FACTORS; HEMORRHAGIC-FEVER; TRANSMISSION; CHILDREN;

D O I：

10.3201/eid2208.160163

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using histories of household members of Ebola virus disease (EVD) survivors in Sierra Leone, we calculated risk of EVD by age and exposure level, adjusting for confounding and clustering, and estimated relative risks. Of 937 household members in 94 households, 448 (48%) had had EVD. Highly correlated with exposure, EVD risk ranged from 83% for touching a corpse to 8% for minimal contact and varied by age group: 43% for children <2 years of age; 30% for those 5-14 years of age; and >60% for adults >= 30 years of age. Compared with risk for persons 20-29 years of age, exposure-adjusted relative risks were lower for those 5-9 (0.70), 10-14 (0.64), and 15-19 (0.71) years of age but not for children <2 (0.92) or 2-4 (0.97) years of age. Lower risk for 5-19-year-olds, after adjustment for exposure, suggests decreased susceptibility in this group.

引用

页码：1403 / 1411

页数：9

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