Turning WAT into BAT gets rid of fat

被引:21
作者
Chen, HC [1 ]
Farese, RV
机构
[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
关键词
D O I
10.1038/nm1001-1102
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several knockout mouse models of leanness and obesity resistance have been reported over the past several years and have advanced our understanding of the pathogenesis and treatment of obesity. A new lean mouse model has been generated by inactivating the gene for an inhibitor of mRNA translation.
引用
收藏
页码:1102 / 1103
页数:2
相关论文
共 13 条
[1]   Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 [J].
Abu-Elheiga, L ;
Matzuk, MM ;
Abo-Hashema, KAH ;
Wakil, SJ .
SCIENCE, 2001, 291 (5513) :2613-2616
[2]   In vivo modulation of Hmgic reduces obesity [J].
Anand, A ;
Chada, K .
NATURE GENETICS, 2000, 24 (04) :377-380
[3]   Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A [J].
Cummings, DE ;
Brandon, EP ;
Planas, JV ;
Motamed, K ;
Idzerda, RL ;
McKnight, GS .
NATURE, 1996, 382 (6592) :622-626
[4]   Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene [J].
Elchebly, M ;
Payette, P ;
Michaliszyn, E ;
Cromlish, W ;
Collins, S ;
Loy, AL ;
Normandin, D ;
Cheng, A ;
Himms-Hagen, J ;
Chan, CC ;
Ramachandran, C ;
Gresser, MJ ;
Tremblay, ML ;
Kennedy, BP .
SCIENCE, 1999, 283 (5407) :1544-1548
[5]   Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice [J].
Klaman, LD ;
Boss, O ;
Peroni, OD ;
Kim, JK ;
Martino, JL ;
Zabolotny, JM ;
Moghal, N ;
Lubkin, M ;
Kim, YB ;
Sharpe, AH ;
Stricker-Krongrad, A ;
Shulman, GI ;
Neel, BG ;
Kahn, BB .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (15) :5479-5489
[6]   PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance [J].
Kubota, N ;
Terauchi, Y ;
Miki, H ;
Tamemoto, H ;
Yamauchi, T ;
Komeda, K ;
Satoh, S ;
Nakano, R ;
Ishii, C ;
Sugiyama, T ;
Eto, K ;
Tsubamoto, Y ;
Okuno, A ;
Murakami, K ;
Sekihara, H ;
Hasegawa, G ;
Naito, M ;
Toyoshima, Y ;
Tanaka, S ;
Shiota, K ;
Kitamura, T ;
Fujita, T ;
Ezaki, O ;
Aizawa, S ;
Nagai, R ;
Tobe, K ;
Kimura, S ;
Kadowaki, T .
MOLECULAR CELL, 1999, 4 (04) :597-609
[7]   Absence of perilipin results in leanness and reverses obesity in Lepr db db mice [J].
Martinez-Botas, J ;
Anderson, JB ;
Tessier, D ;
Lapillonne, A ;
Chang, BHJ ;
Quast, MJ ;
Gorenstein, D ;
Chen, KH ;
Chan, L .
NATURE GENETICS, 2000, 26 (04) :474-479
[8]   Reduced body weight, adipose tissue, and leptin levels despite increased energy intake in female mice lacking acylation-stimulating protein [J].
Murray, I ;
Havel, PJ ;
Sniderman, AD ;
Cianflone, K .
ENDOCRINOLOGY, 2000, 141 (03) :1041-1049
[9]   The mahogany protein is a receptor involved in suppression of obesity [J].
Nagle, DL ;
McGrail, SH ;
Vitale, J ;
Woolf', EA ;
Dussault, BJ ;
DiRocco, L ;
Holmgren, L ;
Montagno, J ;
Bork, P ;
Huszar, D ;
Fairchild-Huntress, V ;
Ge, P ;
Keilty, J ;
Ebeling, C ;
Baldini, L ;
Gilchrist, J ;
Burn, P ;
Carlson, GA ;
Moore, KJ .
NATURE, 1999, 398 (6723) :148-152
[10]   Mice lacking melanin-concentrating hormone are hypophagic and lean [J].
Shimada, M ;
Tritos, NA ;
Lowell, BB ;
Flier, JS ;
Maratos-Flier, E .
NATURE, 1998, 396 (6712) :670-674