Persistence of occult hepatitis B after removal of the hepatitis B virus-infected liver

被引：28

作者：

Ciesek, Sandra ^{[1
]}

Helfritz, Fabian A. ^{[2
]}

Lehmann, Ulrich ^{[3
]}

Becker, Thomas ^{[2
]}

Strassburg, Christian P. ^{[1
]}

Neipp, Michael ^{[2
]}

Ciner, Ayse ^{[1
]}

Fytili, Paraskevi ^{[1
]}

Tillmann, Hans L. ^{[4
]}

Manns, Michael Peter ^{[1
]}

Wedemeyer, Heiner ^{[1
]}

机构：

[1] Hannover Med Sch, Abt Gastroenterol Hepatol & Endokrinol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Clin Gen Visceral & Transplantat Surg, D-30625 Hannover, Germany

[3] Hannover Med Sch, Inst Pathol, D-30625 Hannover, Germany

[4] Univ Leipzig, Dept Gastroenterol & Hepatol, Leipzig, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 03期

关键词：

D O I：

10.1086/525286

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Occult hepatitis B is defined as the persistence of hepatitis B virus (HBV) DNA in persons without HBV surface antigen (HBsAg). The primary site for HBV persistence in persons with occult hepatitis B is considered to be the liver. We provide virological and immunological evidence for long-term persistence of HBV, even after removal of the infected liver, in 25 consecutive, randomly selected liver transplant recipients who tested positive for anti HBV core antigen (anti-HBcAg) and negative for HBsAg at the time of transplantation. Furthermore, in a cohort of 101 anti-HBcAg-positive/HBsAg-negative patients, 2 showed clinical HBV reactivation after transplantation. Thus, these data indicate that a long-term extrahepatic HBV reservoir exists, which is relevant not only for liver transplantation but also for other types of transplantations, including bone marrow grafting.

引用

页码：355 / 360

页数：6

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