The Regulation and Physiology of Mitochondrial Proton Leak

被引：347

作者：

Divakaruni, Ajit S. ^{[1
,2
]}

Brand, Martin D. ^{[1
,2
]}

机构：

[1] Wellcome Trust Res Labs, Med Res Council Mitochondrial Biol Unit, Cambridge, England

[2] Buck Inst Res Aging, Novato, CA USA

来源：

PHYSIOLOGY | 2011年 / 26卷 / 03期

基金：

美国国家科学基金会;

关键词：

BROWN-ADIPOSE-TISSUE; HUMAN UNCOUPLING PROTEIN-3; SKELETAL-MUSCLE MITOCHONDRIA; POLYUNSATURATED FATTY-ACIDS; SPARE RESPIRATORY CAPACITY; BETA-ADRENERGIC-RECEPTORS; DIET-INDUCED OBESITY; FREE-RADICAL THEORY; LIVER-MITOCHONDRIA; INNER MEMBRANE;

D O I：

10.1152/physiol.00046.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.

引用

页码：192 / 205

页数：14

共 231 条

[1] Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy
Adams, Alison E.
Hanrahan, Orla
Nolan, Derek N.
Voorheis, H. Paul
Fallon, Padraic
Porter, Richard K.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 1777 (02): : 115 - 117
[2] Absence of mitochondrial uncoupling protein 1 affects apoptosis in thymocytes, thymocyte/T-cell profile and peripheral T-cell number
Adams, Alison E.
Kelly, Orlagh M.
Porter, Richard K.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2010, 1797 (6-7): : 807 - 816
[3] Stronger control of ATP/ADP by proton leak in pancreatic β-cells than skeletal muscle mitochondria
Affourtit, C
Brand, MD
[J]. BIOCHEMICAL JOURNAL, 2006, 393 : 151 - 159
[4] On the role of uncoupling protein-2 in pancreatic beta cells
Affourtit, Charles
Brand, Martin D.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 1777 (7-8): : 973 - 979
[5] Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion
Affourtit, Charles
Brand, Martin D.
[J]. BIOCHEMICAL JOURNAL, 2008, 409 (199-204) : 199 - 204
[6] MEASURING MITOCHONDRIAL BIOENERGETICS IN INS-1E INSULINOMA CELLS
Affourtit, Charles
Brand, Martin D.
[J]. METHODS IN ENZYMOLOGY, VOL 457: MITOCHONDRIAL FUNCTION, PARTB MITOCHONDRIAL PROTEIN KINASES, PROTEIN PHOSPHATASES AND MITOCHONDRIAL DISEASES, 2009, 457 : 405 - 424
[7] GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart
Aguirre, Enara
Cadenas, Susana
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2010, 1797 (10): : 1716 - 1726
[8] SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
Amat, Ramon
Solanes, Gemma
Giralt, Marta
Villarroya, Francesc
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (47) : 34066 - 34076
[9] Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T
Amo, Taku
Yadava, Nagendra
Oh, Richard
Nicholls, David G.
Brand, Martin D.
[J]. GENE, 2008, 411 (1-2) : 69 - 76
[10] Uncoupling protein-2 regulates lifespan in mice
Andrews, Zane B.
Horvath, Tamas L.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (04): : E621 - E627

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