Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats

被引：28

作者：

Jayasooriya, A. P. ^{[2
]}

Begg, D. P. ^{[1
]}

Chen, N. ^{[2
]}

Mathai, M. L. ^{[2
]}

Sinclair, A. J.

Wilkinson-Berka, J. ^{[3
]}

Wark, J. D. ^{[4
]}

Weisinger, H. S. ^{[1
]}

Weisinger, R. S. ^{[1
,2
]}

机构：

[1] La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3086, Australia

[2] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

[4] Univ Melbourne, Dept Med, Royal Melbourne Hosp, Melbourne, Vic 3010, Australia

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2008年 / 78卷 / 01期

关键词：

D O I：

10.1016/j.plefa.2007.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To establish the effect of dietary omega-3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in omega-3 PUFA from conception. Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the omega-3 PUFA deficient diet were significantly more hypertensive than those fed the omega-3 PUFA sufficient diet. Perindopril reduced the blood pressure of both omega-3 PUFA-deficient and omega-3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by omega-3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that omega-3 PUFA may reduce hypertension via the renin-angiotensin system. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：67 / 72

页数：6

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