Role of Foxp3-positive regulatory T cells during infection

被引：81

作者：

Belkaid, Yasmine ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1002/eji.200738120

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3(+) Treg, have been shown to play a central role in the establishment of these controlled immune responses. In this review, I discuss current hypotheses and points of polemic associated with the origin, mode of action and antigen specificity of Foxp3(+) Treg during infection.

引用

页码：918 / 921

页数：4

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