Chemical modification of rapamycin: The discovery of SDZ RAD

被引:121
作者
Sedrani, R [1 ]
Cottens, S [1 ]
Kallen, J [1 ]
Schuler, W [1 ]
机构
[1] Novartis Pharma AG, Preclin Res, CH-4002 Basel, Switzerland
关键词
D O I
10.1016/S0041-1345(98)00587-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:2192 / 2194
页数:3
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共 10 条
[1]   A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].
BROWN, EJ ;
ALBERS, MW ;
SHIN, TB ;
ICHIKAWA, K ;
KEITH, CT ;
LANE, WS ;
SCHREIBER, SL .
NATURE, 1994, 369 (6483) :756-758
[2]   Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP [J].
Choi, JW ;
Chen, J ;
Schreiber, SL ;
Clardy, J .
SCIENCE, 1996, 273 (5272) :239-242
[3]   PROLONGATION OF RENAL-ALLOGRAFT SURVIVAL IN A LARGE ANIMAL-MODEL BY ORAL RAPAMYCIN MONOTHERAPY [J].
GRANGER, DK ;
CROMWELL, JW ;
CHEN, SC ;
GOSWITZ, JJ ;
MORROW, DT ;
BEIERLE, FA ;
SEHGAL, SN ;
CANAFAX, DM ;
MATAS, AJ .
TRANSPLANTATION, 1995, 59 (02) :183-186
[4]   RAPAMYCIN INHIBITS ARTERIAL INTIMAL THICKENING CAUSED BY BOTH ALLOIMMUNE AND MECHANICAL INJURY - ITS EFFECT ON CELLULAR, GROWTH-FACTOR, AND CYTOKINE RESPONSES IN INJURED VESSELS [J].
GREGORY, CR ;
HUIE, P ;
BILLINGHAM, ME ;
MORRIS, RE .
TRANSPLANTATION, 1993, 55 (06) :1409-1418
[5]   Sirolimus: A new agent for clinical renal transplantation [J].
Kahan, BD .
TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) :48-50
[6]   X-ray crystal structure of 28-O-methylrapamycin complexed with FKBP12: Is the cyclohexyl moiety part of the effector domain of rapamycin? [J].
Kallen, JA ;
Sedrani, R ;
Cottens, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (25) :5857-5861
[7]   RAFT1 - A MAMMALIAN PROTEIN THAT BINDS TO FKBP12 IN A RAPAMYCIN-DEPENDENT FASHION AND IS HOMOLOGOUS TO YEAST TORS [J].
SABATINI, DM ;
ERDJUMENTBROMAGE, H ;
LUI, M ;
TEMPST, P ;
SNYDER, SH .
CELL, 1994, 78 (01) :35-43
[8]   ISOLATION OF A PROTEIN TARGET OF THE FKBP12-RAPAMYCIN COMPLEX IN MAMMALIAN-CELLS [J].
SABERS, CJ ;
MARTIN, MM ;
BRUNN, GJ ;
WILLIAMS, JM ;
DUMONT, FJ ;
WIEDERRECHT, G ;
ABRAHAM, RT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (02) :815-822
[9]   SDZ RAD, a new rapamycin derivative - Pharmacological properties in vitro and in vivo [J].
Schuler, W ;
Sedrani, R ;
Cottens, S ;
Haberlin, B ;
Schulz, M ;
Schuurman, HJ ;
Zenke, G ;
Zerwes, HG ;
Schreier, MH .
TRANSPLANTATION, 1997, 64 (01) :36-42
[10]   SDZ RAD, a new rapamycin derivative - Synergism with cyclosporine [J].
Schuurman, HJ ;
Cottens, S ;
Fuchs, S ;
Joergensen, J ;
Meerloo, T ;
Sedrani, R ;
Tanner, M ;
Zenke, G ;
Schuler, W .
TRANSPLANTATION, 1997, 64 (01) :32-35