White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

High white mattergrade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular Z, size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (it = 3245) mean age 75 years, 50% black and 40% men, we Z, evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting C for numerous determinants of longevity over an approximate 10- 12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years Of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals. (C) 2006 Elsevier Inc. All rights reserved.