Genetic ecotoxicology: The genotypic diversity approach

被引:31
作者
Shugart, LR [1 ]
Theodorakis, C [1 ]
机构
[1] UNIV TENNESSEE, DEPT ENVIRONM TOXICOL, KNOXVILLE, TN 37916 USA
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1996年 / 113卷 / 02期
关键词
DNA; heritable effects; selection; population genetics;
D O I
10.1016/0742-8413(95)02097-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Organismal responses at the genetic level to exposure to environmental genotoxicants have been well documented. An elucidation of the molecular mechanisms involved with these responses, as well as an assessment of the changes that may occur to the genetic material, will provide an understanding of the potential for deleterious consequences at higher levels of biological organization. Moreover, modem procedures of molecular biology offer the hope that alterations and changes to genetic material can be readily detected.
引用
收藏
页码:273 / 276
页数:4
相关论文
共 13 条
[1]   GENETIC AND MOLECULAR ECOTOXICOLOGY - A RESEARCH FRAMEWORK [J].
ANDERSON, S ;
SADINSKI, W ;
SHUGART, L ;
BRUSSARD, P ;
DEPLEDGE, M ;
FORD, T ;
HOSE, J ;
STEGEMAN, J ;
SUK, W ;
WIRGIN, I ;
WOGAN, G .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 :3-8
[2]   SOMATIC AND HERITABLE EFFECTS OF ENVIRONMENTAL GENOTOXINS AND THE EMERGENCE OF EVOLUTIONARY TOXICOLOGY [J].
BICKHAM, JW ;
SMOLEN, MJ .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 :25-28
[3]  
BRUSICK DJ, 1980, PRINCIPLES GENETIC T
[4]  
CLIVE D, 1987, J CLIN RES DRUG DEV, V1, P11
[5]  
DEPLEDGE MH, 1993, NONDESTRUCTIVE BIOMA, P271
[6]  
GUENGERICH FP, 1993, AM SCI, V81, P440
[7]  
Mccarthy JF., 1990, BIOMARKERS ENV CONTA
[8]  
SHHUGART LR, 1995, IN PRESS QUANTITATIV
[9]  
SHUGART L, 1992, SETAC SP P, P125
[10]   ENVIRONMENTAL GENOTOXICITY - PROBING THE UNDERLYING MECHANISMS [J].
SHUGART, L ;
THEODORAKIS, C .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 :13-17