Motor discoordination in mutant mice heterozygous for the type 1 inositol 1,4,5-trisphosphate receptor

被引：58

作者：

Ogura, H

Matsumoto, M

Mikoshiba, K

机构：

[1] Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Mol Neurobiol, Minato Ku, Tokyo 1088639, Japan

[3] RIKEN, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510198, Japan

来源：

BEHAVIOURAL BRAIN RESEARCH | 2001年 / 122卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

inositol 1,4,5-trisphosphate receptor; knockout mice; heterozygous; motor coordination; rotating rod; cerebellum;

D O I：

10.1016/S0166-4328(01)00187-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In the brain, the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) is a major subtype of receptors for inositol 1,4,5-trisphosphate, which mediates the release of calcium from intracellular stores. The motor function of knockout mice heterozygous for IP3R1 (IP3RI + / -) was assessed. An impairment of motor coordination was observed in IP3R1 + / - mice in the rotating rod test. There was no observable difference between genotypes in spontaneous motor activity, grip strength, the hanging test, or walking pattern. These results suggest that IP3RI plays a substantial role in motor coordination. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：215 / 219

页数：5

共 20 条

[1] INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL AS 2ND MESSENGERS [J].