Direct condensation of carboxylic acids with alcohols catalyzed by hafnium(IV) salts

被引:333
作者
Ishihara, K
Ohara, S
Yamamoto, H [1 ]
机构
[1] Nagoya Univ, Core Res Evolut Sci & Technol, Japan Sci & Technol, Grad Sch Engn,Chikusa Ku, Nagoya, Aichi 4648603, Japan
[2] Nagoya Univ, Res Ctr Adv Waste & Emiss Management, Chikusa Ku, Nagoya, Aichi 4648603, Japan
关键词
D O I
10.1126/science.290.5494.1140
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In order to promote atom efficiency in synthesis and to avoid the generation of environmental waste, the use of stoichiometric amounts of condensing reagents OF excess substrates should be avoided. In esterification, excesses of either carboxylic acids or alcohols are normally needed. We show that the direct condensation of equimolar amounts of carboxylic acids and alcohols can be achieved with the use of hafnium(IV) salts, such as commercially available hafnium(IV) chloride and hafnium(IV) tert-butoxide. The present method can be applied to direct polyesterification and may be suitable for large-scale operations.
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页码:1140 / 1142
页数:3
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