A retrospective evaluation of the role of T cells in the development of malaria vaccine

被引：28

作者：

Tsuji, Moriya ^{[1
]}

机构：

[1] Aaron Diamond AIDS Res Ctr, HIV & Malaria Vaccine Program, New York, NY 10016 USA

来源：

EXPERIMENTAL PARASITOLOGY | 2010年 / 126卷 / 03期

关键词：

Malaria; CD8+T cells; CD4+T cells; Hepatic stages; Immunity; Vaccine; SPOROZOITE SURFACE PROTEIN-2; BERGHEI LIVER STAGES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; PLASMODIUM-BERGHEI; GAMMA-INTERFERON; INFECTED HEPATOCYTES; RECOMBINANT ADENOVIRUS; IRRADIATED SPOROZOITES; ANTIGEN PRESENTATION;

D O I：

10.1016/j.exppara.2009.11.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Due to the fact that the life cycle of malaria parasites is complex, undergoing both an extracellular and intracellular phases in its host, the human immune system has to mobilize both the humoral and cellular arms of immune responses to fight against this parasitic infection. Whereas humoral immunity is directed toward the extracellular stages which include sporozoites and merozoites, cell-mediated immunity (CMI), in which T cells play a major role, targets hepatic stages - liver stages - of the parasites. In this review, the role of T cells in protective immunity against liver stages of the malaria infection is being re-evaluated. Furthermore, this review intends to address how to translate the findings regarding the role of T cells obtained in experimental systems to actual development of malaria vaccine for humans. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：421 / 425

页数：5

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