An enantioselective Baylis-Hillman reaction catalyzed by chiral phosphines under atmospheric pressure

被引：107

作者：

Hayase, T

Shibata, T

Soai, K ^{[1
]}

Wakatsuki, Y

机构：

[1] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1628601, Japan

[2] Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 12期

关键词：

D O I：

10.1039/a802594k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) catalyzes the enantioselective Baylis-Hillman reaction between pyrimidine- 5-carbaldehydes and acrylates to provide chiral alpha-methylene beta-hydroxy esters in up to 44% ee under atmospheric pressure.

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收藏

页码：1271 / 1272

页数：2

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