NO-independent stimulators of soluble guanylate cyclase

被引：132

作者：

Straub, A

Stasch, JP

Alonso-Alija, C

Benet-Buchholz, J

Ducke, B

Feurer, A

Fürstner, C

机构：

[1] Bayer AG, Ctr Agr, Pharma Res Ctr, Inst Med Chem, D-40789 Monheim, Germany

[2] Bayer AG, Pharma Res Ctr, Inst Cardiovasc & Arteriosclerosis Res, D-40789 Monheim, Germany

[3] Bayer AG, Div Struct Res, Cent Res, Xray Lab, D-51368 Leverkusen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)00073-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：781 / 784

页数：4

共 18 条

[1] Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line [J].