How does the C-terminal domain (CTD) of RNA polymerase II interact specifically with multiple targets? A recent paper describing the structure of this domain with a mRNA capping enzyme guanylyltransferase suggests that the CTD is a contortionist that, upon post-translational modification, adopts different configurations specifically recognized by its partners.
机构:Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
Fabrega, C
Shen, V
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机构:Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
Shen, V
Shuman, S
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机构:Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
Shuman, S
Lima, CD
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Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USACornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
机构:Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USA
Hampsey, M
Reinberg, D
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Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USARobert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USA
机构:Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
Fabrega, C
Shen, V
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h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
Shen, V
Shuman, S
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
Shuman, S
Lima, CD
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USACornell Univ, Weill Med Coll, Dept Biochem, Struct Biol Program, New York, NY 10021 USA
机构:Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USA
Hampsey, M
Reinberg, D
论文数: 0引用数: 0
h-index: 0
机构:
Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USARobert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USA